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Sulfamethoxazole competitively inhibits dihydropteroate synthase, the enzyme responsible for bacterial conversion of PABA to dihydrofolic acid. Inhibition of ...

  go.drugbank.com

  quizlet.com

  en.wikipedia.org

Trimethoprim/sulfamethoxazole, sold under the brand name Bactrim among others, is a fixed-dose combination antibiotic medication used to treat a variety of ...

  en.wikipedia.org

Mechanism of action ... Trimethoprim inhibits dihydrofolate reductase, the enzyme that catalyzes the last step of bacterial folic acid synthesis (see Fig. 4-7).

  www.sciencedirect.com

  www.cyto.purdue.edu

BACTRIM™ sulfamethoxazole and trimethoprim DS. (double strength) tablets and tablets USP. To reduce the development of drug-resistant bacteria and maintain ...

  www.accessdata.fda.gov

  www.brainkart.com

Trimethoprim exerts antimicrobial activity by blocking the reduction of dihydrofolate to tetrahydrofolate, the active form of folic acid, by susceptible ...

  pubmed.ncbi.nlm.nih.gov

  tip10.info

19 мар. 2024 г. ... SUMMARY AND RECOMMENDATIONS · INTRODUCTION · MECHANISM OF ACTION · RESISTANCE · SPECTRUM OF ACTIVITY · PHARMACODYNAMICS AND PHARMACOKINETICS · DOSAGE ...

  www.uptodate.com

  courses.lumenlearning.com

Mechanism of Action ... Sulfamethoxazole is hepatically metabolized by the CYP450 system; it is a CYP2C9 inhibitor. Its half-life is 6 to 12 hours, increasing to ...

  www.ncbi.nlm.nih.gov

  www.ndrugs.com

  www.youtube.com

Mechanism of Action: ... Sulfamethoxazole inhibits the synthesis of dihydrofolic acid. Trimethoprim inhibits thymidine and DNA synthesis. These two agents act ...

  antimicrobe.org

This sequential blockade of 2 enzymes in one pathway results in an effective bactericidal action. The drug was introduced in the late 1960s based on several ...

  jamanetwork.com

Trimethoprim exerts antimicrobial activity by blocking the reduction of dihydrofolate to tetrahydrofolate, the active form of folic acid, by susceptible ...

  accpjournals.onlinelibrary.wiley.com

  www.columbia.edu

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