Trimethoprim/sulfamethoxazole, sold under the brand name Bactrim among others, is a fixed-dose combination antibiotic medication used to treat a variety of ...
en.wikipedia.org19 мар. 2024 г. ... MECHANISM OF ACTION · RESISTANCE · SPECTRUM OF ACTIVITY · PHARMACODYNAMICS AND PHARMACOKINETICS · DOSAGE AND ADMINISTRATION · Approach for most ...
www.uptodate.comTrimethoprim exerts antimicrobial activity by blocking the reduction of dihydrofolate to tetrahydrofolate, the active form of folic acid, by susceptible ...
accpjournals.onlinelibrary.wiley.comIt is generally given in combination with trimethoprim, a dihydrofolate reductase inhibitor, which inhibits the reduction of dihydrofolic acid to ...
go.drugbank.comMechanism of Action ... Sulfamethoxazole is hepatically metabolized by the CYP450 system; it is a CYP2C9 inhibitor. Its half-life is 6 to 12 hours, increasing to ...
www.ncbi.nlm.nih.govMechanism of action of trimethoprim-sulfamethoxazole. II.
pubmed.ncbi.nlm.nih.govBACTRIM™ sulfamethoxazole and trimethoprim DS. (double strength) tablets and tablets USP. To reduce the development of drug-resistant bacteria and maintain ...
www.accessdata.fda.govTrimethoprim (TMP) selectively inhibits microbial reductases, but its effectiveness is strikingly enhanced when the synthesis of FAH2 is simultaneously blocked ...
academic.oup.comThis sequential blockade of 2 enzymes in one pathway results in an effective bactericidal action. The drug was introduced in the late 1960s based on several ...
jamanetwork.comMechanism of action of trimethoprim-sulfamethoxazole. I.
pubmed.ncbi.nlm.nih.gov